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20 March 2026

慢性阻塞性肺疾病合并肺癌研究进展
—— 共同危险因素及发病机制

倩倩 卢1 丽 李1
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1 右江民族医学院附属西南医院, 中国
MRP 2026 , 4(3), 10–14; https://doi.org/10.61369/MRP.2026030009
© 2026 by the Author(s). Licensee Art and Technology, USA. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
Abstract

慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)和肺癌是世界范围内导致死亡的疾病之一,给全球带来了沉重社会和经济负担。COPD和肺癌的共病高发提示二者可能存在共同的危险因素和发病机制。其中吸烟、环境空气污染是二者共同的危险因素。越来越多的证据显示,慢性炎症、遗传易感性、表观遗传、端粒长度、慢性炎症、氧化应激反应和肺部微生物等是COPD和肺癌发生发展的共同通路。本文就COPD合并肺癌的主要危险因素及共同发病机制作一综述,为疾病早期早期筛查、诊断及治疗策略提供依据。

Keywords
肺癌
慢性阻塞性肺疾病
慢性阻塞性肺疾病合并肺癌
危险因素
共同发病机制
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