肝硬化诊断及分级中25（OH）D3、IGF-1、高尔基体蛋白73的临床价值研究

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Abstract

目的：探究肝硬化诊断及分级中25（OH）D3、IGF-1、高尔基体蛋白73的临床价值研究。方法：于2024年2月~2025年9月，选取本院收治的肝硬化患者60例，所有患者以肝脏活检病理切片为诊断肝硬化的“金标准”，另选取我院进行健康体检的健康人群60例，分析25（OH）D3、IGF-1、高尔基体蛋白73在两组人群中的含量，分析三项联合的灵敏度、特异度、准确度。结果：与对照组相比，研究组25（OH）D3上升，IGF-1、高尔基体蛋白73下降，有差异性（P<0.05）；本研究还发现，三项联合诊断高于单独检测，表明三项联合检测的阳性检出率较高（P＜0.05）；与单项检测相比，三项联合联合诊断肝硬化患者的灵敏度、特异度、准确度更高。结论：检测肝硬化患者血清25（OH）D3、IGF-1和高尔基体蛋白73水平的变化，可以有效提高诊断检出率并可以减轻患者活检的风险，同时联合检测对早期肝硬化有较高的诊断价值。

Keywords

肝硬化

诊断

25（OH）D3

IGF-1

高尔基体蛋白73

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