Volume 4,Issue 9
KMSC-Exos 联合中医药改善急性肾损伤研究进展
急性肾损伤(Acute Kidney Injury,AKI)应归入临床危重症类,其诱因很多、病理过程较复杂,目前尚缺少针对病因的精确干预及特异药物疗法。以肾脏间充质干细胞为来源的外泌体(KMSC-Exos)是新出现的生物治疗形式,所具有的低免疫原性及组织趋化性对再生有较大意义,但体内靶向效率的提高仍是其临床应用的主要障碍。现将有关肾脏间充质干细胞(KMSCs)及所释外泌体治疗AKI 的研究做一归纳性总结,对KMSC-Exos 修复AKI 的机制作初步分析;同时提出用该类疗法配合中医药治疗AKI 的可能性,希望由此找到突破AKI 转化难题的全新思路。
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