Volume 4,Issue 9
circRNA-miRNA-mRNA 网络解析AVF血管重塑机制
自体动静脉内瘘(Arteriovenous Fistula,AVF)狭窄与转录后调控驱动的血管重构密切相关。测序共筛得211个差异miRNA 和866个差异circRNA。ceRNA 分析提示,miR-665/miR-296轴可能通过调控CREB3L1和RXFP1,促进平滑肌细胞增殖及炎症、纤维化反应,参与内瘘失功进程。该轴有望作为AVF 狭窄的潜在预警与干预靶点。
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